Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that is being developed for the treatment of obesity. It is not currently approved for any use by the US Food and Drug Administration (FDA). However, it is in Phase III clinical trials for the treatment of obesity, and it is expected to be submitted for FDA approval in 2023.
Tesofensine works by blocking the reuptake of serotonin, norepinephrine, and dopamine in the brain. This increases the levels of these neurotransmitters in the brain, which can lead to a number of effects, including:
- Reduced appetite
- Increased feelings of fullness
- Increased energy expenditure
- Improved mood
In clinical trials, tesofensine has been shown to be effective in reducing body weight and body fat in people with obesity. In one study, participants who took tesofensine for 24 weeks lost an average of 12.6% of their body weight, compared to 6.5% in participants who took a placebo.
Tesofensine is also well-tolerated in most people. The most common side effects are mild and go away on their own, such as dry mouth, nausea, and insomnia.
In addition to its potential for the treatment of obesity, tesofensine is also being investigated for the treatment of other conditions, such as:
- Parkinson’s disease
- Alzheimer’s disease
- Attention deficit hyperactivity disorder (ADHD)
- Depression
However, more research is needed to confirm the safety and efficacy of tesofensine for these conditions.
Potential benefits of tesofensine for weight loss:
- Effective in reducing body weight and body fat
- Well-tolerated in most people
- May also improve mood
Potential risks of tesofensine:
- Cardiovascular safety concerns: Tesofensine has been associated with an increased risk of heart attack and stroke in some studies. However, more research is needed to confirm this risk.
- Other side effects: The most common side effects of tesofensine are mild and go away on their own, such as dry mouth, nausea, and insomnia. However, more serious side effects are also possible.
Overall, tesofensine is a promising new drug for the treatment of obesity. However, it is important to note that it is not currently approved for any use, and more research is needed to confirm its safety and efficacy. If you are considering taking tesofensine, it is important to talk to your doctor about the risks and benefits.
