MOTS-c, or Mitochondrial Open Reading Frame of the 12S rRNA-c, is a 16-amino-acid peptide that is encoded by the mitochondrial 12S rRNA gene. It is a relatively new peptide that was first discovered in 2013. MOTS-c is produced in the mitochondria, the energy factories of the cell, and it is transported to the nucleus, where it regulates the expression of genes involved in metabolism and stress response.
MOTS-c and metabolism
MOTS-c plays a role in regulating a variety of metabolic processes, including glucose metabolism, lipid metabolism, and energy production. It has been shown to improve insulin sensitivity, promote glucose uptake into muscle cells, and increase fat burning. MOTS-c also helps to protect the mitochondria from damage and to promote mitochondrial biogenesis, the process of creating new mitochondria.
MOTS-c and stress response
MOTS-c also plays a role in regulating the body’s stress response. It has been shown to reduce inflammation, protect against oxidative damage, and promote cellular repair. MOTS-c also helps to regulate the circadian rhythm, the body’s natural sleep-wake cycle.
Potential benefits of MOTS-c
MOTS-c is a promising new therapeutic target for a variety of conditions, including:
- Obesity: MOTS-c has been shown to promote weight loss and improve body composition in animal studies.
- Diabetes: MOTS-c has been shown to improve insulin sensitivity and glucose metabolism in animal studies.
- Muscle wasting: MOTS-c has been shown to increase muscle mass and strength in animal studies.
- Osteoporosis: MOTS-c has been shown to increase bone density and reduce the risk of fractures in animal studies.
- Neurological disorders: MOTS-c has been shown to protect against neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease in animal studies.
- Cardiovascular disease: MOTS-c has been shown to protect against heart disease and stroke in animal studies.
MOTS-c research
Research on MOTS-c is still in its early stages, but the results so far are promising. More research is needed to confirm the safety and efficacy of MOTS-c in humans and to determine the optimal dosage and formulation.
MOTS-c supplements
MOTS-c supplements are becoming increasingly popular among bodybuilders and athletes, who believe that they can help to improve muscle mass, strength, and performance. However, it is important to note that there is limited scientific evidence to support the use of MOTS-c supplements for these purposes.
Safety and side effects of MOTS-c
MOTS-c is generally safe and well-tolerated. However, it can cause some side effects, such as increased appetite, weight gain, headache, nausea, and vomiting. MOTS-c can also interact with other medications. If you are taking any other medications, talk to your doctor before taking MOTS-c supplements.
MOTS-c is a promising new therapeutic target for a variety of conditions. Research is ongoing to determine the safety and efficacy of MOTS-c in humans and to develop new MOTS-c formulations.
