Bremelanotide, also known as PT-141, is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH). It is a small peptide hormone that acts on melanocortin receptors in the brain and body.
α-MSH is a naturally occurring hormone that plays a role in a variety of physiological processes, including skin pigmentation, appetite regulation, and sexual function. Bremelanotide is a more potent and longer-acting version of α-MSH.
Bremelanotide is currently approved by the FDA for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women. It is the first and only FDA-approved drug for the treatment of HSDD in women.
Bremelanotide is also being investigated for the treatment of other conditions, including erectile dysfunction, premature ejaculation, and female orgasmic disorder.
How does bremelanotide work?
Bremelanotide works by stimulating melanocortin receptors in the brain. These receptors are involved in a variety of physiological processes, including sexual function.
When bremelanotide binds to melanocortin receptors in the brain, it increases the release of dopamine. Dopamine is a neurotransmitter that plays a key role in sexual function.
Bremelanotide also increases blood flow to the genitals. This can improve sexual arousal and response.
How is bremelanotide used?
Bremelanotide is administered as a subcutaneous injection. It is typically injected into the abdomen or thigh.
Bremelanotide is taken on an as-needed basis, 45 minutes before sexual activity.
Side effects of bremelanotide
Bremelanotide is generally well-tolerated, but some people may experience side effects such as:
- Flushing
- Nausea
- Headache
- Dizziness
- Hypotension
- Injection site reactions
In rare cases, bremelanotide can cause more serious side effects, such as:
- Seizures
- Allergic reactions
- Liver toxicity
Bremelanotide is not recommended for people with certain medical conditions, such as:
- Cardiovascular disease
- Liver disease
- Kidney disease
- Seizure disorders
- Mental health disorders
Bremelanotide is a promising new drug for the treatment of sexual dysfunction in men and women. It is the first and only FDA-approved drug for the treatment of HSDD in women.
Bremelanotide is generally well-tolerated, but some people may experience side effects. It is important to talk to your doctor before taking bremelanotide to discuss the risks and benefits.
Please note that bremelanotide is not a magic bullet. It will not work for everyone, and it is important to have realistic expectations.
