5-amino-1MQ, also known as 5-amino-1-methylquinoline, is a small molecule drug that is currently being investigated for its potential to promote weight loss, improve metabolic health, and extend lifespan. It works by inhibiting an enzyme called nicotinamide N-methyltransferase (NNMT), which plays a role in regulating metabolism and energy production.
NNMT is most active in fat tissue, where it converts nicotinamide (NAM) to 1-methylnicotinamide (1-MNA). 1-MNA is a byproduct of metabolism that can accumulate in fat cells and lead to insulin resistance and other metabolic problems.
By blocking NNMT, 5-amino-1MQ increases levels of NAM in the body. NAM is a precursor to nicotinamide adenine dinucleotide (NAD+), a cofactor that is essential for many cellular processes, including metabolism, energy production, and DNA repair.
NAD+ levels decline with age, which is thought to contribute to the development of age-related diseases such as obesity, diabetes, and heart disease. 5-amino-1MQ may help to protect against these diseases by increasing NAD+ levels in the body.
Potential benefits of 5-amino-1MQ
5-amino-1MQ is still under investigation, but it has shown promise in a number of preclinical and clinical studies. Some of the potential benefits of 5-amino-1MQ include:
- Weight loss: 5-amino-1MQ has been shown to promote weight loss and reduce fat mass in animal studies. In a clinical study, participants who took 5-amino-1MQ for 12 weeks lost significantly more weight and body fat than those who took a placebo.
- Improved metabolic health: 5-amino-1MQ has been shown to improve metabolic health markers such as insulin sensitivity, blood sugar control, and cholesterol levels in animal and human studies.
- Extended lifespan: 5-amino-1MQ has been shown to extend lifespan in animal studies. In one study, mice that were given 5-amino-1MQ lived up to 30% longer than mice that did not receive the drug.
How to take 5-amino-1MQ
5-amino-1MQ is currently available as a prescription drug in some countries. It is typically taken orally once or twice a day.
The recommended dosage of 5-amino-1MQ varies depending on the individual’s condition and the desired effects. For weight loss, the recommended dosage is typically 100-200 mg per day. For improved metabolic health and longevity, the recommended dosage is typically 50-100 mg per day.
Side effects of 5-amino-1MQ
5-amino-1MQ is generally well-tolerated. Some people may experience mild side effects such as nausea, vomiting, and diarrhea. These side effects are typically mild and go away on their own within a few days of starting treatment.
5-amino-1MQ may interact with certain medications, so it is important to talk to your doctor before starting treatment.
Research on 5-amino-1MQ is ongoing
5-amino-1MQ is a promising new drug with the potential to promote weight loss, improve metabolic health, and extend lifespan. However, more research is needed to confirm these benefits and to determine the long-term safety of 5-amino-1MQ.
If you are considering taking 5-amino-1MQ, it is important to talk to your doctor to see if it is right for you.
More information on the potential benefits of 5-amino-1MQ
Weight loss
5-amino-1MQ may promote weight loss by increasing metabolism and reducing fat accumulation. In animal studies, 5-amino-1MQ has been shown to increase the expression of genes involved in fat burning and to decrease the expression of genes involved in fat storage.
In a clinical study, participants who took 5-amino-1MQ for 12 weeks lost significantly more weight and body fat than those who took a placebo. The participants who took 5-amino-1MQ also lost more visceral fat, which is a type of fat that is stored around the organs and is associated with an increased risk of chronic diseases.
Improved metabolic health
5-amino-1MQ may improve metabolic health by increasing insulin sensitivity, improving blood sugar control, and reducing cholesterol levels. In animal studies, 5-amino-1MQ has been shown to improve insulin sensitivity and to reduce blood sugar levels in both diabetic and non-diabetic animals.
In a clinical study, participants who took 5-amino-1MQ for 12 weeks showed significant improvements in insulin sensitivity, blood sugar control, and cholesterol levels.
