Tesofensine peptide is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that is being developed for the treatment of obesity. It is not currently approved for any use by the US Food and Drug Administration (FDA). However, it is in Phase III clinical trials for the treatment of obesity, and it is expected to be submitted for FDA approval in 2023.
Tesofensine peptide works by blocking the reuptake of serotonin, norepinephrine, and dopamine in the brain. This increases the levels of these neurotransmitters in the brain, which can lead to a number of effects, including:
- Reduced appetite
- Increased feelings of fullness
- Increased energy expenditure
- Improved mood
Tesofensine peptide has been shown to be effective in reducing body weight and body fat in clinical trials. In one study, participants who took tesofensine for 24 weeks lost an average of 12.6% of their body weight, compared to 6.5% in participants who took a placebo.
Tesofensine peptide is also well-tolerated in most people. The most common side effects are mild and go away on their own, such as:
- Dry mouth
- Nausea
- Insomnia
- Constipation
- Headache
- Dizziness
- Fatigue
- Anxiety
- Increased heart rate
- Increased blood pressure
However, more serious side effects are also possible, such as:
- Cardiovascular events (e.g., heart attack, stroke)
- Psychiatric events (e.g., depression, suicidal thoughts)
- Allergic reactions
If you are considering taking tesofensine peptide, it is important to talk to your doctor about the risks and benefits. Tesofensine peptide may interact with other medications you are taking, and it is important to make sure that it is safe for you to take.
Here are some additional things to keep in mind about the side effects of tesofensine peptide:
- The most common side effects of tesofensine peptide are mild and go away on their own after a few days or weeks of treatment.
- Serious side effects are rare, but they can occur.
- It is important to tell your doctor about any side effects you experience, even if they are mild.
- Your doctor may need to adjust your dose of tesofensine peptide or prescribe other medications to manage the side effects.
If you have any concerns about the side effects of tesofensine peptide, please talk to your doctor.
