Pentosan polysulfate sodium (PPS), also known as Elmiron, is a prescription medication used to treat bladder pain syndrome/interstitial cystitis (BPS/IC). BPS/IC is a chronic bladder condition that causes pain, pressure, and discomfort in the bladder and pelvic region. PPS is thought to work by coating and protecting the lining of the bladder, which can help to reduce inflammation and pain.
PPS is generally well-tolerated, but some side effects may occur. The most common side effects of PPS are mild and go away on their own within a few days of starting treatment. These side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Hair loss
Less common side effects of PPS include:
- Stomach pain
- Heartburn
- Rash
- Difficulty sleeping
- Mood changes
- Vision changes
- Ringing in the ears
- Numbness and tingling in the hands and feet
A rare side effect of PPS is pigmentary maculopathy, an eye condition that can lead to vision loss. Pigmentary maculopathy has been reported in a small number of people who have taken PPS for long periods of time.
If you experience any side effects while taking PPS, be sure to talk to your doctor. They can help you to determine if the side effects are serious and if you need to stop taking PPS.
How to reduce the risk of side effects from PPS
There are a few things you can do to reduce the risk of side effects from PPS:
- Take PPS with food. This can help to reduce stomach upset.
- Start with a low dose of PPS and gradually increase the dose as tolerated.
- Avoid taking PPS if you are allergic to it.
- Talk to your doctor about other medications you are taking, as some medications may interact with PPS.
If you experience any side effects while taking PPS, be sure to talk to your doctor. They can help you to determine if the side effects are serious and if you need to stop taking PPS.
