MK-677, also known as ibutamoren, is a growth hormone secretagogue (GHS) that mimics the effects of the natural hormone ghrelin. Ghrelin is a peptide hormone that is released by the stomach and stimulates the release of growth hormone from the pituitary gland.
MK-677 is a potent oral GHS that has been shown to increase growth hormone levels by up to 20-fold. It is also a long-acting GHS, with a half-life of 4-6 hours.
MK-677 is not yet approved by the FDA for any use in humans, but it is being investigated for a variety of potential therapeutic applications, including:
- Growth hormone deficiency
- Muscle wasting
- Osteoporosis
- Wound healing
- Athletic performance
In addition to these potential therapeutic applications, MK-677 is also popular among bodybuilders and other athletes for its ability to increase muscle mass and strength.
However, MK-677 can cause some side effects, including:
- Increased appetite
- Weight gain
- Headache
- Nausea
- Vomiting
- Joint pain
- Muscle pain
- Insomnia
- Carpal tunnel syndrome
- Increased prolactin levels
Increased appetite and weight gain
MK-677 can cause increased appetite and weight gain by increasing the levels of the hunger hormone ghrelin and decreasing the levels of the satiety hormone leptin. This can lead to weight gain, especially in people who are already overweight or obese.
Headache, nausea, and vomiting
MK-677 can cause headache, nausea, and vomiting by increasing the levels of growth hormone and insulin-like growth factor-1 (IGF-1). These hormones can upset the stomach and cause nausea and vomiting.
Joint pain and muscle pain
MK-677 can cause joint pain and muscle pain by increasing the production of collagen. Collagen is a protein that is found in bones and muscles. When collagen production is increased, it can put stress on the joints and muscles, leading to pain.
Insomnia
MK-677 can cause insomnia by increasing the levels of growth hormone and IGF-1. These hormones can interfere with sleep, making it difficult to fall asleep and stay asleep.
Carpal tunnel syndrome
MK-677 can cause carpal tunnel syndrome by increasing the amount of fluid in the body. This fluid can build up in the carpal tunnel, which is a narrow passageway in the wrist that contains nerves and tendons. When the carpal tunnel becomes inflamed, it can compress the nerves, leading to pain, numbness, and tingling in the hands and fingers.
Increased prolactin levels
MK-677 can increase prolactin levels. Prolactin is a hormone that is responsible for milk production in women. In men, high prolactin levels can lead to erectile dysfunction, decreased libido, and breast tenderness.
If you are considering taking MK-677, it is important to talk to your doctor first. They can help you to determine if MK-677 is right for you and can monitor you for any side effects.
