Pentosan polysulfate sodium (PPS) is a prescription medication used to treat bladder pain syndrome/interstitial cystitis (BPS/IC). It is also known as Elmiron.
PPS is a semi-synthetic glycosaminoglycan (GAG). GAGs are a type of sugar molecule that is found naturally in the body. GAGs play a role in a variety of functions, including cell communication, cell growth, and tissue repair.
PPS is derived from hemicellulose, a type of polysaccharide that is found in the cell walls of plants. Hemicellulose is made up of a variety of sugar molecules, including xylose. PPS is created by chemically modifying xylose to create a long chain of sugar molecules.
PPS is a water-soluble molecule, which means that it can dissolve in water. This makes it easy for PPS to be absorbed into the bloodstream and distributed to the tissues of the body.
PPS is also a very stable molecule. It is not easily broken down by enzymes or other chemicals in the body. This makes PPS a long-lasting medication.
How Pentosan Polysulfate Peptide Works
The exact mechanism of action of PPS is not fully understood, but it is thought to work by a combination of mechanisms, including:
- Protecting the bladder lining from irritation and inflammation
- Reducing inflammation
- Improving blood flow to the bladder
- Reducing scar tissue formation
Other Potential Uses of Pentosan Polysulfate Peptide
In addition to its use for BPS/IC, PPS is also being investigated for potential use in the treatment of other conditions, such as:
- Osteoarthritis
- Painful bowel syndrome
- Vulvodynia
- Interstitial cystitis in men
- Radiation cystitis
- Chemotherapy-induced cystitis
- Overactive bladder
- Recurrent urinary tract infections
Side Effects of Pentosan Polysulfate Peptide
PPS is generally well-tolerated, but some side effects may occur, such as:
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Hair loss
- Pigmentary maculopathy (a rare eye condition that can lead to vision loss)
Pentosan polysulfate sodium (PPS) is a prescription medication used to treat bladder pain syndrome/interstitial cystitis (BPS/IC). It is also known as Elmiron. PPS is a safe and effective medication for most people with BPS/IC. However, some people may not respond to PPS or may experience side effects that make it not a good option for them.
If you are considering taking PPS, it is important to talk to your doctor first. Your doctor can help you to determine if PPS is right for you and can monitor you for any side effects.
