Methylcobalamin, also known as MeCbl, is a cobalamin, a form of vitamin B12. It is the active form of vitamin B12, meaning that it is the form that the body can use most easily.
Methylcobalamin has a complex chemical structure that consists of a central cobalt atom surrounded by a corrin ring. The corrin ring is a large, planar molecule that is made up of four pyrrole rings. The cobalt atom is bonded to the corrin ring through four nitrogen atoms.
Methylcobalamin also has a methyl group attached to the cobalt atom. The methyl group is a small molecule that is made up of one carbon atom and three hydrogen atoms.
The chemical structure of methylcobalamin is important for its biological activity. The corrin ring helps to protect the cobalt atom from oxidation. The methyl group is essential for methylcobalamin’s ability to donate methyl groups to other molecules.
Methylcobalamin in the body
Methylcobalamin is an essential nutrient that is involved in many important bodily functions, including:
- Red blood cell production
- DNA synthesis
- Nerve function
- Myelin production
Methylcobalamin is absorbed from the small intestine and then transported to the liver. The liver stores methylcobalamin and releases it into the bloodstream as needed.
Methylcobalamin is transported in the bloodstream by a protein called transcobalamin II. Transcobalamin II delivers methylcobalamin to cells throughout the body.
Methylcobalamin deficiency
Methylcobalamin deficiency can be caused by a number of factors, including:
- Pernicious anemia
- Celiac disease
- Crohn’s disease
- Ulcerative colitis
- Gastric bypass surgery
- Strict vegetarian or vegan diet
Symptoms of methylcobalamin deficiency can include:
- Fatigue
- Weakness
- Numbness and tingling in the hands and feet
- Pale skin
- Shortness of breath
- Diarrhea
- Constipation
- Loss of appetite
- Memory loss
- Mood changes
Methylcobalamin supplements
Methylcobalamin supplements are available in a variety of forms, including capsules, tablets, and liquid drops. Methylcobalamin supplements can be purchased over-the-counter at most pharmacies and health food stores.
The dosage of methylcobalamin supplements will vary depending on the individual’s needs. It is important to talk to your doctor before taking methylcobalamin supplements, especially if you have any underlying health conditions.
Safety and side effects of methylcobalamin
Methylcobalamin is generally safe for most people to take. However, it can cause some side effects, such as:
- Nausea
- Vomiting
- Diarrhea
- Allergic reaction (rare)
If you experience any side effects after taking methylcobalamin, stop taking it and talk to your doctor.
Methylcobalamin is an essential nutrient that is important for many bodily functions. Methylcobalamin deficiency can cause a variety of symptoms, including fatigue, weakness, numbness and tingling in the hands and feet, pale skin, shortness of breath, diarrhea, constipation, loss of appetite, memory loss, and mood changes.
Methylcobalamin supplements are available over-the-counter at most pharmacies and health food stores. It is important to talk to your doctor before taking methylcobalamin supplements, especially if you have any underlying health conditions.
