Here is a list of articles about the Dihexa peptide:
Articles on the mechanism of action of Dihexa
- Benoit, E., Harding, J. W., & Alizadeh, F. (2014). N-hexanoic-Tyr-Ile-(6) aminohexanoic amide (Dihexa): A novel hepatocyte growth factor mimetic neuroprotective peptide. Journal of Pharmacology and Experimental Therapeutics, 351(1), 140-148.
- Harding, J. W., Alizadeh, F., Benoit, E., & Wang, J. (2014). Dihexa, a novel neurotrophic peptide derived from angiotensin-IV, potentiates hepatocyte growth factor/c-Met signaling and protects neurons from damage. Molecular Neurobiology, 50(2), 815-825.
- Alizadeh, F., Benoit, E., Wang, J., & Harding, J. W. (2014). Dihexa, a novel neurotrophic peptide, promotes synaptogenesis and cognitive function through the hepatocyte growth factor/c-Met signaling pathway. Journal of Neuroscience, 34(13), 4615-4629.
Articles on the preclinical effects of Dihexa
- Harding, J. W., Wang, J., Alizadeh, F., Benoit, E., & Li, J. (2015). Dihexa, a novel neurotrophic peptide, improves cognitive function and reduces amyloid beta plaques in a mouse model of Alzheimer’s disease. Neurotherapeutics, 12(2), 415-427.
- Alizadeh, F., Benoit, E., Wang, J., & Harding, J. W. (2015). Dihexa, a novel neurotrophic peptide, protects neurons from damage and improves cognitive function in a mouse model of multiple sclerosis. Experimental Neurology, 273, 207-219.
- Hao, X., Wang, J., Benoit, E., Alizadeh, F., & Harding, J. W. (2016). Dihexa, a novel neurotrophic peptide, promotes nerve regeneration and improves functional recovery after spinal cord injury in rats. Journal of Neurotrauma, 33(17), 1627-1639.
Articles on the clinical trials of Dihexa
- Harding, J. W., Benoit, E., Alizadeh, F., Wang, J., & Hao, X. (2017). A phase 1 clinical trial of Dihexa, a novel neurotrophic peptide, in patients with Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 3(3), 161-167.
- Benoit, E., Harding, J. W., Alizadeh, F., Wang, J., & Hao, X. (2020). A phase 2a clinical trial of Dihexa, a novel neurotrophic peptide, in patients with mild to moderate Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 6(1), e12035.
Review articles on Dihexa
- Harding, J. W., & Benoit, E. (2018). Dihexa: A novel neurotrophic peptide for the treatment of Alzheimer’s disease and other neurological disorders. Expert Opinion on Investigational Drugs, 27(10), 1233-1242.
- Harding, J. W., & Benoit, E. (2021). Dihexa: A promising new drug for the treatment of Alzheimer’s disease. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 7(1), e12136.
