Kisspeptin-10 peptide is also known as:
- Metastin-45-54
- KISS1-10
- GPR54-LP10
- KP-10
- Decapeptidyl-kisspeptin
Kisspeptin-10 peptide is a synthetic form of kisspeptin-10, a naturally occurring hormone that plays a key role in the regulation of the reproductive system. Kisspeptin-10 peptide is a decapeptide, meaning that it is composed of 10 amino acids. Its amino acid sequence is:
H-His-Trp-Asn-Phe-NF-Phe-Leu-Tyr-NH2
The NF-Phe residue in kisspeptin-10 peptide is a modified amino acid that is essential for its biological activity.
Kisspeptin-10 peptide was first discovered in 2001 by two independent research groups. The first group, led by Dr. Allan Herbison at the University of Melbourne, discovered kisspeptin-10 peptide in the hypothalamus of sheep. The second group, led by Dr. Stephen Seminara at the University of Pittsburgh, discovered kisspeptin-10 peptide in the testes of mice.
Kisspeptin-10 peptide is produced in a variety of tissues, including the hypothalamus, pituitary gland, gonads, and pancreas. Kisspeptin-10 peptide acts on a receptor called the kisspeptin receptor (KISS1R), which is found on a variety of cell types, including neurons in the hypothalamus, pituitary gland, and gonads.
When kisspeptin-10 peptide binds to the KISS1R, it triggers a signaling cascade that leads to the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. GnRH travels to the anterior pituitary gland and stimulates the release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are essential for the development and function of the reproductive system.
Kisspeptin-10 peptide plays a key role in the initiation of puberty, the menstrual cycle, and ovulation. Kisspeptin-10 peptide is also important for fertility in men and women.
Kisspeptin-10 peptide is still under development as a therapeutic agent, but it has the potential to be used to treat a variety of conditions, including:
- Hypogonadotropic hypogonadism (HH)
- Delayed puberty
- Amenorrhea
- Infertility
- Polycystic ovary syndrome (PCOS)
- Obesity
- Diabetes
- Alzheimer’s disease
Kisspeptin-10 peptide research is a rapidly growing field, and there is a lot of excitement about the potential of this peptide to treat a variety of conditions.
