Tesofensine is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). This means that it works by blocking the reuptake of serotonin, norepinephrine, and dopamine in the brain. Reuptake is the process by which these neurotransmitters are removed from the synapse (the space between two nerve cells) after they have been released. By blocking reuptake, tesofensine increases the levels of these neurotransmitters in the brain.
Serotonin, norepinephrine, and dopamine are all involved in the regulation of appetite, mood, and energy expenditure. Increasing the levels of these neurotransmitters in the brain can lead to a number of effects, including:
- Reduced appetite
- Increased feelings of fullness
- Increased energy expenditure
- Improved mood
These effects can all contribute to weight loss.
In addition to its effects on appetite and energy expenditure, tesofensine may also work by increasing the production of heat in the body. This process is known as thermogenesis. Thermogenesis can help to increase the number of calories burned by the body each day.
Overall, tesofensine is a complex drug that works in a number of ways to promote weight loss. More research is needed to fully understand all of the mechanisms by which tesofensine works.
Here is a more detailed explanation of how tesofensine affects each of the three neurotransmitters that it targets:
- Serotonin: Serotonin is a neurotransmitter that plays a role in many different functions in the body, including appetite, mood, and sleep. Increasing serotonin levels in the brain can lead to a decrease in appetite and an increase in feelings of fullness.
- Norepinephrine: Norepinephrine is a neurotransmitter that plays a role in the body’s fight-or-flight response. It also plays a role in appetite and energy expenditure. Increasing norepinephrine levels in the brain can lead to an increase in energy expenditure and a decrease in appetite.
- Dopamine: Dopamine is a neurotransmitter that plays a role in motivation, reward, and learning. It also plays a role in appetite and food cravings. Increasing dopamine levels in the brain can lead to a decrease in food cravings and an increase in motivation to exercise.
Tesofensine is a promising new drug for the treatment of obesity. However, it is important to note that it is not currently approved for any use, and more research is needed to confirm its safety and efficacy. If you are considering taking tesofensine, it is important to talk to your doctor about the risks and benefits.
