Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is a small oligopeptide drug derived from angiotensin IV. It is currently being investigated for the treatment of Alzheimer’s disease and other neurological disorders.
Dihexa is thought to work by potentiating the activity of hepatocyte growth factor (HGF) at its receptor, c-Met. HGF is a potent neurotrophic factor that plays an important role in the development and maintenance of the nervous system. It also has neuroprotective and regenerative effects.
HGF signaling plays a role in a variety of cellular processes, including cell growth, differentiation, and survival. In the brain, HGF signaling plays a role in the development and maintenance of neurons and synapses.
Dihexa is thought to potentiate the activity of HGF by increasing the binding affinity of HGF for its receptor, c-Met. This leads to increased activation of the c-Met signaling pathway, which has a number of beneficial effects on the brain, including:
- Increased neurogenesis (the growth of new neurons)
- Increased synaptogenesis (the formation of new synapses)
- Neuroprotection (protection of neurons from damage)
- Enhanced nerve regeneration
Dihexa has also been shown to reduce inflammation in the brain. Inflammation is thought to play a role in the development and progression of Alzheimer’s disease.
How Dihexa might help with Alzheimer’s disease
Alzheimer’s disease is a neurodegenerative disease that is characterized by the loss of neurons and synapses in the brain. It is also characterized by the accumulation of amyloid beta plaques and tau tangles in the brain.
Dihexa may help with Alzheimer’s disease by:
- Increasing neurogenesis and synaptogenesis
- Protecting neurons from damage
- Enhancing nerve regeneration
- Reducing inflammation
Other potential benefits of Dihexa
Dihexa is also being investigated for the treatment of other neurological disorders, such as Parkinson’s disease, multiple sclerosis, and spinal cord injury. Preclinical studies have shown that Dihexa can improve cognitive function and protect neurons from damage in these disorders.
Dihexa is also being investigated for the treatment of cognitive impairment in cancer patients who are undergoing chemotherapy. Chemotherapy can cause a number of side effects, including cognitive impairment. Dihexa is thought to be able to protect neurons from damage caused by chemotherapy and improve cognitive function in cancer patients.
Safety and side effects
Dihexa has been shown to be safe and well-tolerated in clinical trials. However, some people may experience side effects such as nausea, vomiting, diarrhea, and headache. Dihexa is not recommended for pregnant or breastfeeding women.
Dihexa is a promising new drug for the treatment of Alzheimer’s disease and other neurological disorders. It is currently in Phase 2 clinical trials for the treatment of Alzheimer’s disease, and the results of these trials are eagerly awaited.
